Here I did some testing with filters.
Trees look better with FFXAA on but other than trees I have not seen difference. If someone saw improvement in other areas please post screenshots.
FXAA on
FXAA off
Here is Aida Flower shop. With FXAA on the 7 number looks a little blurred
FXAA on
Here the number 7 does not looks blurred.It looks better in my opinion.
FXAA off
Cartoon in my opinion can make a better job than FXAA it can make the game more colorful and bright and affects everything.It makes trees look more colorful and lively.
Cartoon On
Cartoon Off
With Cartoon on coca cola machine looks very nice and bright and tomato signs too. It looks better with more internet resolution.
Cartoon On
Cartoon Off
In my opinion 32 max layers is a most to have perfect emulation without graphical glitches during smoke or dust.
Filters FXAA does not make a huge difference. In my opinion is better to turn it off if it causes slowdowns.Its better to leave the anti-aliasing work to your graphics video card.
Cartoon is a better filter in my opinion. Turned both cartoon and FXAA makes no difference because you will only see Cartoon filter on.
Internal resolution x2 + 32 max layers is all you really need is very beautiful and is going to give you the HD feel.
It really depends on the size of your screen to take advantage of a higher internal resolution.
1x: 640x480.
2x: 1280x960.
3x: 1920x1440.
4x: 2560x1920.
5x: 3200x2400.
6x: 3840x2880.