^Indeed. Similar hardware here, but I have a 970 myself ( much weaker ) and 6x IR and 32 layers isn't feasible. Even 3-4 IR will occasionally give drops in Shen II, especially when there is heavy smoke effects going on. The newer GPU plugins are really nice, and pretty accurate when compared to something like NullDC, but they are not very well optimized at the current time. Hopefully in the future we will be able to push it much harder without the need to brute force everything. Even on low end cards.
Don't let Demul scare you about that choice of rig though. You will have more than enough for emulating most systems. For instance, you will smash through PS2/GC/Wii if you wanted to without any trouble